@ATXJane
Hey Jane, glad you’re ok.

Fire away, what is it you’d like to ask?

@VaKnow22 Given that your black dog lurked around in your life for so long...Have you ever done genetic testing to see if you have the genetic quirk on the MTHFR gene? That might explain some stuff...

@ATXJane
To be honest, I’ve never even heard of it?! 😬

I’m going to have to have a quick Google. 🤦‍♂️

@VaKnow22 This could be a game changer for you. It basically influences the metabolism of serotonin. And now we're at the end of my genetics knowledge. Methylated folate supplement is the key, but it should be added to your diet under supervision, particularly if you're on antidepressants.

@ATXJane
Ah thanks for this. I’m seeing my doctor for a check up next week. I’ll ask and find out.

Really appreciate the message, anything to help manage my depression is massively welcome!!

@VaKnow22 A little more background: I suspected the MTHFR variant in our extended family because you could trace those of us who were often chronically melancholy alternating with depressed *independent of life circumstances*. Then when I took a CE class in psychopharmacology, the speaker talked about working with people with "treatment resistant depression."

@VaKnow22 Because her clients were indigenous poor, she just tried methylated folate rather than doing the more expensive genetic testing. She said if they came in happier 2 weeks later she felt almost 100% confident they had the variant. I believe there's an RX supplement but you can now find methylated folate OTC at least in the US.

@VaKnow22 I can't make dose recommendations and of course I'm not offering medical advice, only my own experience, but the doses are pretty low. I have a hunch this info might be helpful - and I truly hope it is. Thanks for for being so gracious.

@ATXJane
Really interesting, thank you 🙏

I’ll let you know how I get on!!

@VaKnow22 Please do. I'd really love to hear back! :)