It is fundamental to the Newtonian paradigm that the set of possibilities that constitute the phase space is always definable and fixed ahead of time. This fails for the diachronic evolution of ever-new adaptations in any biosphere.

https://royalsocietypublishing.org/doi/pdf/10.1098/rsfs.2022.0063

@johnverdon
I will get back to you on this...
Reading pile is huge right now.

@corlin Kauffman is always worth the read - but also a must read is the Philip Ball article "How Life Really Works"
https://nautil.us/how-life-really-works-435813/