DW put her foot down & insisted on buying a portable a/c for our bedroom, despite the fact that we have (in theory anyway) central air. It's bulky and noisy and was a surprising pain to install.
OMG am I in love with this thing. So cool in there now, and all through the night.
We affectionately refer to it as "the Blorgon"
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The central air doesn't really make it to the top floor of the house, I think b/c the ductwork was designed for heat only.
@rpardee We have to adjust the registers. Full open upstairs, partially open downstairs.
Keeping fan mode on also helps.