An interesting point from "A City on Mars".
If you assume that attempts will be made to set up a colony on the Moon or Mars, you're talking about having a massive construction site in gravity that's a fraction of Earth's.
We don't know a fucking thing about trauma medicine in fractional gravities. We don't know much about ANESTHESIA in fractional gravities, except if you're a RAT.
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@mcfate we do know that bacteria grows at a dramatically faster rate, so any workers injured or sick in that environment will be at risk levels not seen since the days of the wild west, if not worse.
The sheer magnitude of such an operation is filled with so many unknowns and known dangers that I doubt we'll see it in our great grandchildren's lifetimes.