Follow
chrome://flags/#omnibox-suggestion-transparency-options
and enable the flag.
After a reset, you’ll now have the option to simply click a small “X” to the right of any URL suggestion in the omnibar to remove it as a quick suggestion moving forward. No shortcuts, no keyboards, no weird settings.
This is what most users will be looking for when wanting to remove a suggested URL
https://chromeunboxed.com/google-chrome-url-omnibar-suggestions-clear-remove/