Psilocybin—the hallucinogen in magic mushrooms—continues to show promise as an anti-depressant, especially when combined with psychotherapy. Meanwhile though, it's being explored for treating anxiety, OCD, irritable bowel syndrome, and other disorders.
https://www.nature.com/articles/s44220-024-00332-z.epdf
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@thewebrecluse when chemically isolated, does it still cause nausea? I tried them once and was miserable with stomach upset. How that could help IBS seems wonky.