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Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases #LungDisease
-This discovery has implications for conditions associated with epithelial barrier dysfunction, basal cell hyperplasia, and continued turnover of dying cells in patients with chronic inflammatory pulmonary diseases.
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The tyrosine kinase inhibitors, ligand traps, and monoclonal antibodies already developed could therefore be repurposed for chronic inflammatory diseases such as COPD, which itself is associated with eventual development of lung cancer.
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